Protons Confirmation of Glimepiride drug using Correlation Spectroscopy a unique tool of Nuclear Magnetic Resonance spectroscopy

The power of Nuclear Magnetic Resonance spectroscopy (NMR) in structure elucidation derives in large part from its ability to establish bonding connectivity (via Jcoupling interaction) or through space proximity (via dipolar coupling interactions) of nuclei. The amount of time consumed in elucidating a structure depends on the rate at which these interaction can be detected by NMR and analyzed.1D NMR methods most often explore interactions between only few nuclei at a time: spin-spin decoupling measurements are used to demonstrate through-bond connectivity; and NOE measurements are used to probe inter-nuclear distances, 2-Dimensional NMR experiments provide much more structural information in a given time period. Correlation spectroscopy was used to elucidate the aromatic proton position in NMR spectra.